Ginger essential oil-loaded hydrogels: preparation, characterization, cytotoxicity, antimicrobial and anti-inflammatory activity


ARPA M. D., KESMEN E. E., ARSLAN T., KARADAĞ A. E., BİLTEKİN KALELİ S. N., DEMİRCİ F.

Journal of Essential Oil Research, vol.36, no.1, pp.16-29, 2024 (SCI-Expanded) identifier

  • Publication Type: Article / Article
  • Volume: 36 Issue: 1
  • Publication Date: 2024
  • Doi Number: 10.1080/10412905.2023.2299854
  • Journal Name: Journal of Essential Oil Research
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, Business Source Elite, Business Source Premier, CAB Abstracts, Compendex, Food Science & Technology Abstracts, Veterinary Science Database
  • Page Numbers: pp.16-29
  • Keywords: anti-inflammatory, antimicrobial, formulation, hydrogel, Zingiber officinale
  • Istanbul Medipol University Affiliated: Yes

Abstract

The present study aimed to develop ginger essential oil hydrogel formulations, using sodium carboxymethyl cellulose (Na CMC), Carbopol, and xanthan gum for dental and oromucosal infections. The physicochemical properties of the hydrogels were evaluated, and their bioadhesive characteristics were determined. Antimicrobial activity, cytotoxicity, and lipoxygenase (LOX) inhibitory activities of the essential oil and its formulations were investigated, respectively. The major components of ginger essential oil were confirmed as α-zingiberene (39.0%) and ar-curcumene (23.7%) by GC-FID and GC/MS analyses. The initial results showed that none of the tested gel formulations selected for the application were non-cytotoxic. According to antimicrobial and LOX enzyme activity studies, the essential oil-loaded xanthan gum gel (X3) was more effective compared to the essential oil itself. The initial formulation and biological evaluation studies concluded that ginger essential oil hydrogels (X3, C3) can be further developed for oral and dental health by providing a long residence time due to their bioadhesive properties.