Studies on synthesis, chromatographic resolution, and antiinflammatory activities of some 2-thioxo-1,2,3,4-tetrahydropyrimidines and their condensed derivatives

Tozkoparan B., Yarim M., Saraç S., Ertan M., Kelicen P., Altinok G., ...Daha Fazla

Archiv der Pharmazie, cilt.333, sa.12, ss.415-420, 2000 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 333 Sayı: 12
  • Basım Tarihi: 2000
  • Dergi Adı: Archiv der Pharmazie
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.415-420
  • Anahtar Kelimeler: antiinflammatory agents, 2-thioxo-1,2,3,4-tetrahydropyrimidines, 5H-thiazolo[3,2-a]pyrimidines, enantioseparation, morphological findings
  • İstanbul Medipol Üniversitesi Adresli: Hayır

Özet

In this study, the synthesis of some new 2-thioxo-1,2,3,4-tetrahydropyrimidines and their condensed derivatives, thiazolo[3,2-a]pyrimidines, are described. The structures of the compounds were confirmed by IR, 1H-NMR, 13C-NMR, and mass spectroscopy. The direct high-performance liquid chromatographic separation of the compounds on derivatized cellulose chiral stationary phases such as cellulose tris(3,5-dimethylphenylcarbamate) (OD), cellulose tris(4-methylphenylcarbamate) (OG), and cellulose tris(4-methylbenzoate) (OJ) was studied. All of the compounds were screened for their antiinflammatory activity and also investigated histopathologically. Compounds 3 and 1a were found to be the most promising antiinflammatory agents in this group.