Ruthenium-Anchored Ag2Se Quantum Dots for Enhanced Near-Infrared Antibacterial Nanotherapeutics
Small, 2026 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Basım Tarihi: 2026
- Doi Numarası: 10.1002/smll.76023
- Dergi Adı: Small
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Aerospace Database, Chemical Abstracts Core, Chimica, Compendex, EMBASE, INSPEC, MEDLINE, Biomedical Reference Collection: Corporate Edition (EBSCO), Materials Science & Engineering Collection (ProQuest), Technology Collection (ProQuest)
- Anahtar Kelimeler: Ag2Se, antibacterial, bacteria, infrared, metal, quantum dot, reactive oxygen species, ROS, transition metal
- İstanbul Medipol Üniversitesi Adresli: Evet
Özet
Light-activated nanotherapeutics that generate reactive oxygen species (ROS) offer a resistance-independent antibacterial strategy. However, integrating transition metals with inorganic quantum dots (QDs) to modulate light–matter interactions and extend photoactivity into the near-infrared (NIR) windows remains largely unexplored for antibacterial applications. Here, we develop a colloidal in situ integration strategy to anchor metallic ruthenium (Ru) onto Ag2Se QDs, enabling broadband-enhanced photoresponse and multimodal generation of superoxide, hydroxyl radicals, and singlet oxygen, alongside a high photothermal conversion efficiency of 66.4%. Moreover, Ru decoration transforms the previously unstable Ag2Se QDs into highly robust colloidal suspensions. The Ru-decorated Ag2Se QDs exhibit potent photodynamic and photothermal antibacterial activity against Gram-negative Escherichia coli and Gram-positive Staphylococcus aureus under near-infrared (NIR-I and NIR-II) irradiation, extending therapeutic photoactivation beyond the visible range. Ultimately, this work introduces an unconventional biomedical nanoplatform that integrates transition metals with inorganic quantum dots for advanced functionality.