Domain-general and domain-specific functional networks of Broca's area underlying language processing

Bulut T.

Brain and Behavior, cilt.13, sa.7, 2023 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 13 Sayı: 7
  • Basım Tarihi: 2023
  • Doi Numarası: 10.1002/brb3.3046
  • Dergi Adı: Brain and Behavior
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, EMBASE, MEDLINE, Directory of Open Access Journals
  • Anahtar Kelimeler: Broca's area, domain-general, domain-specific, functional connectivity, language, meta-analytic connectivity modeling
  • İstanbul Medipol Üniversitesi Adresli: Hayır

Özet

Introduction: Despite abundant research on the role of Broca's area in language processing, there is still no consensus on language specificity of this region and its connectivity network. Methods: The present study employed the meta-analytic connectivity modeling procedure to identify and compare domain-specific (language-specific) and domain-general (shared between language and other domains) functional connectivity patterns of three subdivisions within the broadly defined Broca's area: pars opercularis (IFGop), pars triangularis (IFGtri), and pars orbitalis (IFGorb) of the left inferior frontal gyrus. Results: The findings revealed a left-lateralized frontotemporal network for all regions of interest underlying domain-specific linguistic functions. The domain-general network, however, spanned frontoparietal regions that overlap with the multiple-demand network and subcortical regions spanning the thalamus and the basal ganglia. Conclusions: The findings suggest that language specificity of Broca's area emerges within a left-lateralized frontotemporal network, and that domain-general resources are garnered from frontoparietal and subcortical networks when required by task demands.