Acute effects of grayanotoxin in rhododendron honey on kidney functions in rats

SİLİCİ S., Doğan Z., ŞAHİN H., ATAYOĞLU A. T., YAKAN B.

Environmental Science and Pollution Research, vol.23, no.4, pp.3300-3309, 2016 (SCI-Expanded) identifier identifier

  • Publication Type: Article / Article
  • Volume: 23 Issue: 4
  • Publication Date: 2016
  • Doi Number: 10.1007/s11356-015-5534-z
  • Journal Name: Environmental Science and Pollution Research
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.3300-3309
  • Keywords: Biochemical parameters, Gryanotoxin, Mad honey poisoning, Rat, Rhododendron honey
  • Istanbul Medipol University Affiliated: Yes

Abstract

The aim of the study is to evaluate the acute biochemical and histological changes in rat kidneys after treatment with grayanotoxin (GTX) of rhododendron honey (RH). A total of 60 Sprague–Dawley female rats were divided into five groups of 12 rats each, one being a control group (group 1) and group 2 was treated with 0.015 mg/kg/bw of GTX standard preparation via intraperitoneal injection. Groups 3, 4, and 5 were given RH at doses of 0.1, 0.5, and 2.5 g/kg/bw, respectively, via oral gavage. Compared to the control group, significant increases were observed in glucose, blood urea nitrogen (BUN), and creatinine levels of the GTX-injected groups after 1 h. However, in low dose RH group, such an increase was not observed and had a normal appearance histologically. Therefore, low dose (1 g/kg/bw) of RH produces no acute adverse effects on renal functions of rats.