Transplantation Tolerance: The Next Frontier

Hülya B., ÖZDİLLİ K., Oǧuz F. S.

Turkish Journal of Immunology, vol.8, no.1-2, pp.11-20, 2003 (Scopus) identifier

  • Publication Type: Article / Review
  • Volume: 8 Issue: 1-2
  • Publication Date: 2003
  • Journal Name: Turkish Journal of Immunology
  • Journal Indexes: Scopus
  • Page Numbers: pp.11-20
  • Keywords: Regulatory T-cells, Tolerance, Transplantation
  • Istanbul Medipol University Affiliated: No


The use of allogeneic transplantation as a curative or life extending therapy for a variety of life threatening diseases has increased rapidly. With the extended usage of transplantation in a variety of diseases with success a reasonable improvement in cure rates has been gained in especially high risk patients as a life saving application. But HLA barrier limits its usage. So acquired immunologic tolerance, now known to be possible, has been the ultimate goal of transplantation medicine. T cell antigen receptor (TCR) plays a central role in the immune response and has dual potential to transmit activation signals that lead to tolerance or anergy.In this review the mechanisms that control the generation of anergic and regulatory T-cells and new therapeutic approaches for the development of antigen specific tolerance for allogeneic transplantation is discussed. Such treatment approaches will not only expand the the donor pool but will enable us to reduce the use of immunosuppression which cause opportunistic infections and secondary malignancies.