Low serum insulin-like growth factor-1 in patients with erectile dysfunction

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Otunctemur A., Ozbek E., Sahin S., Ozcan L., Dursun M., Polat E. C., ...More

Basic and Clinical Andrology, vol.26, no.1, 2016 (Scopus) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 26 Issue: 1
  • Publication Date: 2016
  • Doi Number: 10.1186/s12610-015-0028-x
  • Journal Name: Basic and Clinical Andrology
  • Journal Indexes: Scopus
  • Keywords: Endothelial dysfunction, Erectile dysfunction, Insulin-like growth factor-1, International Index of Erectile Function Score-5
  • Istanbul Medipol University Affiliated: Yes


Objective: Endothelial dysfunction and microvascular damage play a crurical role in the pathogenesis of erectile dysfunction (ED). Insulin-like growth factor-1 (IGF-1) is one of the growth factors that have a wide range of biologic effects. IGF-1 is an important mediator of cell growth, differentiation and transformation in various tissues. The purpose of the current study was to determine the association between IGF-1 levels and ED. Materials and methods: All men were evaluated for ED and divided into two groups: 80 patients suffering from ED for > 1 year and 80 subjects without ED were enrolled as a control group in this study. Diagnosis of ED was based on the International Index of Erectile Function Score-5. IGF-1 levels were measured in serum by an automated chemiluminescence immunoassay. The relationship between IGF-1 levels and ED scores in patients was statistically evaluated. Results: The mean age of patients in ED group was 60.4 ± 11.3 years and 55.4 ± 9.6 in control group. The plasma IGF-1 levels were significantly lower in ED than in control group (96.5 ± 38.3 and 132.5 ± 53.3 ng/ mL, respectively, P < 0.001). The IGF-1 levels were positively correlated with ED score (r = 0.623, P < 0.01). Conclusion: In this study serum IGF-1 levels were found to be associated with endothelial dysfunction that predicts ED. Serum IGF-1 level appears to be a specific predictor of ED, and it might be used in early prediction of ED in male population.