Chemogenetic tools for causal cellular and neuronal biology

Atasoy D., Sternson S. M.

Physiological Reviews, vol.98, no.1, pp.391-418, 2018 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 98 Issue: 1
  • Publication Date: 2018
  • Doi Number: 10.1152/physrev.00009.2017
  • Journal Name: Physiological Reviews
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.391-418
  • Istanbul Medipol University Affiliated: Yes


Chemogenetic technologies enable selective pharmacological control of specific cell populations. An increasing number of approaches have been developed that modulate different signaling pathways. Selective pharmacological control over G protein-coupled receptor signaling, ion channel conductances, protein association, protein stability, and small molecule targeting allows modulation of cellular processes in distinct cell types. Here, we review these chemogenetic technologies and instances of their applications in complex tissues in vivo and ex vivo.