Synthesis and initial biological evaluation of substituted 1-phenylamino-2-thio-4,5-dimethyl-1H-imidazole derivatives

YURTTAŞ L., DURAN M., Demirayak Ş., Gençer H. K., TUNALI Y.

Bioorganic and Medicinal Chemistry Letters, vol.23, no.24, pp.6764-6768, 2013 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 23 Issue: 24
  • Publication Date: 2013
  • Doi Number: 10.1016/j.bmcl.2013.10.024
  • Journal Name: Bioorganic and Medicinal Chemistry Letters
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.6764-6768
  • Keywords: Imidazole, Antimicrobial, Brine-Shrimp test, Anticancer
  • Istanbul Medipol University Affiliated: Yes


In this work, some new 2-[(4,5-dimethyl-1-(arylamino)-1H-imidazol-2-yl) thio]-1-(aryl)ethanone derivatives were synthesized and investigated for their antibacterial, antifungal and anticancer activities. Toxicity of the most effective compounds was established by performing Brine-Shrimp lethality assay. Antifungal activity of the compounds was found to be higher than antibacterial and anticancer activities of the compounds. © 2013 Elsevier Ltd. All rights reserved.