Elevated serum interleukin 17A level in patients with permature acute coronary syndrome Prematür akut koroner sendrom hastalarinda yüksek serum interlökin-17A düzeyi

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Demir B., Ünʇan I., Oflar E., Khankishiyev V., Pirhan O., Demir E., ...More

Turkiye Klinikleri Cardiovascular Sciences, vol.27, no.2, pp.53-60, 2015 (Scopus) identifier

  • Publication Type: Article / Article
  • Volume: 27 Issue: 2
  • Publication Date: 2015
  • Doi Number: 10.5336/cardiosci.2015-44447
  • Journal Name: Turkiye Klinikleri Cardiovascular Sciences
  • Journal Indexes: Scopus
  • Page Numbers: pp.53-60
  • Keywords: Acute coronary syndrome, Coronary angiography, Inflammation, Interleukin-17
  • Istanbul Medipol University Affiliated: Yes


Objective: To evaluate serum interleukin (IL)-17A level in patients with premature acute coronary syndrome. Material and Methods: Forty-five consecutive patients younger than 45 years (35 males, 10 females, mean age 39.6±3.85 years) admitted to our emergency service and diagnosed with acute coronary syndrome between December 2013 and January 2015 formed the premature acute coronary syndrome group. Thirty-five consecutive subjects with normal coronary arteries on coronary angiography (19 males, 16 females, mean age; 40.1±3.37 years) formed the control group. Syntax score was calculated to determine the extent of coronary lesions in the patient group. Serum IL-17A level was determined by the ELISA method. Results: Males and smokers had a significantly higher percentage in the patient group (for both, p<0.05). The control group had a significantly more common family history of coronary artery disease (p=0.003). Plasma triglyceride, white blood cell count, neutrophil count, neutrophil/lymphocyte ratio were significantly greater in the patient group (for all, p<0.05). Plasma HDL was significantly lower in the patient group (p=0.001). Serum IL-17A was significantly higher in the patient group (2.0±1.88 pg/mL, 0.9±1.86 pg/mL, respectively; p=0.0001). Both groups were similar with respect to serum hs-CRP (4.4±5.61 mg/L, 2.7±6.19 mg/L, respectively; p=0.050). Conclusion: IL-17A, with its proin-flammatory properties, may play a role in premature acute coronary syndrome.