Examination of the Effect of Periodontal Disease on Salivary Gas6 and MFG-E8 Proteins

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Yılmaz M., Türkmen E., Balcı N., Toygar H.

international archieves of dental sciences, cilt.46, sa.2, ss.99-103, 2025 (TRDizin)

Özet

INTRODUCTION: Periodontal disease is a chronic inflammatory process whose primary etiological factor is microbial dental plaque. MFG-E8 is known to play a role in the regulation of apoptotic pathways, angiogenesis, and the maintenance of tissue homeostasis. Gas-6 protein is reported to have effects on cell proliferation and adhesion, as well as the phagocytosis of apoptotic cells and platelet aggregation. The aim of this study is to elucidate the role of Gas6 and MFG-E8 molecules in the pathogenesis of periodontal disease.
METHODS: The study included 20 healthy individuals and 20 patients with stage 3 grade B periodontitis who applied to clinic for dental treatment. Clinical periodontal parameters were recorded, and the levels of Gas6 and MFG-E8 in saliva samples were evaluated using ELISA kits.
RESULTS: Salivary MFG-E8 level in the periodontitis group was significantly lower than healthy participants (p: 0.021). Salivary MFG-E8 level showed a negative correlation with SCD among the clinical parameters (r: -0.082, p < 0.05). There was no significant difference in salivary Gas-6 levels between the control and periodontitis groups (p: 0.282).
DISCUSSION AND CONCLUSION: The lower amount of salivary MFG-E8 in individuals with periodontal disease compared to healthy individuals suggests that MFG-E8 is an effective molecule for tissue homeostasis.