Antimicrobial evaluation of trisubstituted 2-piperazinyl thiazoles

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Giray B., YURTTAŞ L., Şahin Z., Berk B., Demirayak Ş.

Acta Pharmaceutica Sciencia, cilt.57, sa.1, ss.103-108, 2019 (Scopus) identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 57 Sayı: 1
  • Basım Tarihi: 2019
  • Doi Numarası: 10.23893/1307-2080.aps.05707
  • Dergi Adı: Acta Pharmaceutica Sciencia
  • Derginin Tarandığı İndeksler: Scopus
  • Sayfa Sayıları: ss.103-108
  • Anahtar Kelimeler: Antimicrobial, N-benzoylthioamide, Piperazine, Thiazole, Trisubstituted thiazole
  • İstanbul Medipol Üniversitesi Adresli: Evet

Özet

Thiazole and basic nitrogen containing rings are important chemical moieties of antimicrobial drugs. In recent, third generation cephalosporins include thiazole ring system. In this study, we synthesized 33 piperazine thiazole derivatives which were thought to show antimicrobial activity. Synthesize were realized with good yield using the method which reports the anticholinesterase properties of these compounds. Similar compounds with the same scaffold (2, 4, 5 trisubstituted thiazoles) are investigated for antimicrobial activity. Compounds 23-27 exhibited MIC: 256 μM against S. aureus ATCC 25923. Besides, 27-33 group showed MIC: 256 μM against K. pneumoniae UC57 and B. cereus. It is remarkable that the compound 27 showed antimicrobial activity against 4 different microorganisms and 26 showed antimicrobial activity against L. monocytogenes by MIC: 32 μM which is same as the standart chloramphenicol.