Increased CRP/albumin ratio is associated with superfi cial venous refl ux disease and varicose vein formation

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Unal O., Oztas D. M., Beyaz M. O., Erdinc I., Meric M., Ulukan M. O., ...More

Cor et Vasa, vol.63, no.4, pp.430-434, 2021 (ESCI) identifier identifier

  • Publication Type: Article / Article
  • Volume: 63 Issue: 4
  • Publication Date: 2021
  • Doi Number: 10.33678/cor.2021.012
  • Journal Name: Cor et Vasa
  • Journal Indexes: Emerging Sources Citation Index (ESCI), Scopus, EMBASE
  • Page Numbers: pp.430-434
  • Keywords: Albumin, CRP, Inflammation, Superficial venous reflux disease, Varicose veins
  • Istanbul Medipol University Affiliated: Yes


Background: It has been recently postulated that infl ammation may have an effect on varicose vein development and prognosis, besides increased venous pressure. CRP/albumin (CAR) is a novel infl ammatory marker associated with poor prognosis in a various group of patients. Our aim in this study was to investigate the relation between varicose greater saphenous vein (VSM) diameter and CAR. Methods: A total of 150 patients with patients VSM insuffi ciency (Group 1, n: 114) and normal VSM (n: 36) were included in the study. The diameter of the VSM was measured with B-mode ultrasound, and refl ux was quantifi ed based on valve closure time using Doppler spectral tracings. Blood samples were taken during recruitment. The CAR value is determined by dividing the serum CRP level to the albumin level. Results: There were 21 (18.4%) males and 93 (81.5%) females in Group 1 and 7 males and 29 females in Group 2. Mean age of the patients were similar in both groups (48.02-12.20 years in Group 1 vs. 44.9-8.92 years in Group 2, p = 0.44). Mean BMI of the patients did not differ signifi cantly (Group 1: 26.4-3.7 kg/m2 correvs. Group 2: 25.7-4.2 kg/m2, p = 0.13). The mean diameter of VSM was measured 5.70-0.29 mm in Group 1 whereas 3.21-0.34 mm in Group 2 (p = 0.0023). Mean CRP and albumin values in Group 1 were 6.18-4.99 mg/L and 4.45-0.27 g/dL whereas 4.25-2.46 mg/L and 6.18-1.14 g/dL in Group 2, respectively (p value for CRP = 0.049, p value for albumin = 0.074). CRP/albumin was 1.28-1.34 in Group 1 and 1.11-1.21 in Group 2, which was not statistically signifi cant (p = 0.58). There was a positive moderately strong correlation between VSM diameter and CRP/albumin ratio as well as superfi cial venous refl ux disease (r: 0.48). Conclusion: CRP/albumin ratio is associated with increased incidence of varicose veins and increased diameter of greater saphenous vein; hence, superfi cial venous refl ux disease. The fi ndings support the hypothesis that systemic infl ammation may play a role in varicose vein disease.