Role of apoptosis in common variable immunodeficiency and selective immunoglobulin A deficiency

Yazdani R., Fatholahi M., Ganjalikhani-Hakemi M., Abolhassani H., Azizi G., Hamid K. M., ...Daha Fazla

Molecular Immunology, cilt.71, ss.1-9, 2016 (SCI-Expanded) identifier identifier

  • Yayın Türü: Makale / Derleme
  • Cilt numarası: 71
  • Basım Tarihi: 2016
  • Doi Numarası: 10.1016/j.molimm.2015.12.016
  • Dergi Adı: Molecular Immunology
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.1-9
  • Anahtar Kelimeler: Apoptosis, Common variable immunodeficiency, IgA deficiency
  • İstanbul Medipol Üniversitesi Adresli: Hayır

Özet

Common variable immunodeficiency (CVID) and selective IgA deficiency (SIgAD) are the most common primary immunodeficiencies in human. Both diseases share clinical manifestation and molecular defects. Increased apoptosis may be one of the mechanisms involved in the pathogenesis of CVID and SIgAD. Elevated apoptosis in this disorder leads to defective long-term survival of B-cells, reduced antibody production, decreased lymphocyte proliferation and defective cytokine secretion. For the first time, we reviewed the role of apoptosis in CVID and SIgAD.