Synthesis of some N-[4-(benzothiazole-2yl) phenyl]-2-aryloxyacetamide derivatives and their anticancer activities

TAY N. F., YURTTAŞ L., Demirayak Ş.

Journal of Enzyme Inhibition and Medicinal Chemistry, cilt.27, sa.4, ss.515-520, 2012 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 27 Sayı: 4
  • Basım Tarihi: 2012
  • Doi Numarası: 10.3109/14756366.2011.599030
  • Dergi Adı: Journal of Enzyme Inhibition and Medicinal Chemistry
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.515-520
  • Anahtar Kelimeler: Benzothiazole, antitumour, non-small cell lung cancer, prostate cancer
  • İstanbul Medipol Üniversitesi Adresli: Evet

Özet

In this study, some N-[4-(Benzothiazole-2-yl) phenyl]-2-aryloxyacetamide derivatives were prepared by reacting N-[4-(benzothiazole-2yl)phenyl]-2- chloroacetamide and different substituent phenol or thiophenol derivatives. The anticancer activities of the compounds obtained were investigated. It was observed that some of the compounds, namely 25 and 38, showed notable anticancer activity. © 2012 Informa UK, Ltd.