Synthesis of some N-[4-(benzothiazole-2yl) phenyl]-2-aryloxyacetamide derivatives and their anticancer activities

TAY N. F., YURTTAŞ L., Demirayak Ş.

Journal of Enzyme Inhibition and Medicinal Chemistry, vol.27, no.4, pp.515-520, 2012 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 27 Issue: 4
  • Publication Date: 2012
  • Doi Number: 10.3109/14756366.2011.599030
  • Journal Name: Journal of Enzyme Inhibition and Medicinal Chemistry
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.515-520
  • Keywords: Benzothiazole, antitumour, non-small cell lung cancer, prostate cancer
  • Istanbul Medipol University Affiliated: Yes


In this study, some N-[4-(Benzothiazole-2-yl) phenyl]-2-aryloxyacetamide derivatives were prepared by reacting N-[4-(benzothiazole-2yl)phenyl]-2- chloroacetamide and different substituent phenol or thiophenol derivatives. The anticancer activities of the compounds obtained were investigated. It was observed that some of the compounds, namely 25 and 38, showed notable anticancer activity. © 2012 Informa UK, Ltd.