Use of livers from hepatitis B core antibody positive donors in living donor liver transplantation

Yaprak O., DAYANGAÇ M., Balci D., Demirbas T., Yuzer Y., Tokat Y.

Hepato-Gastroenterology, vol.57, no.102-103, pp.1268-1271, 2010 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 57 Issue: 102-103
  • Publication Date: 2010
  • Journal Name: Hepato-Gastroenterology
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.1268-1271
  • Keywords: De novo hepatitis B, Liver transplantation, Anti-HBc positive donor
  • Istanbul Medipol University Affiliated: Yes


Background/Aims: HBsAg negative recipients of liver from anti-HBc positive donors are at a significant risk for developing de novo HBV infection after liver transplantation. The aim of this study was to assess the efficacy of lamivudine as mono therapy in preventing HBV transmission by graft with anti-HBc positive donors. Methodology: Between June 2004 and January 2009, 40 of 250 recipients received liver grafts from donors with anti-HBc positive in our centre. We analyzed 18 recipients with negative HBsAg who have at least follow-up of 6 months. All recipients and donors were negative for HBsAg and serum HBV DNA. Eleven of 18 patients had received liver grafts from living donor, while others from deceased donor. Mean age of these 18 patients was 49 (range, 25 to 66). Mean followup for patients receiving anti-HBc positive donor graft was 18.7 months (range, 6 to 48 months). Lamivudine mono-prophylaxis was given to all recipients since first post-transplant day. Recipient serological markers including HBsAg, HBV-DNA, anti-HBs, anti-HBc were routinely tested every 3 months or when liver function was abnormal. Results: One patient who discontinued lamivudine prophylaxis developed de novo HBV infection in 21 months after liver transplantation. Seventeen patients under lamivudine prophylaxis remained negative for serum HBsAg and HBV-DNA with a follow-up of 17 months. Conclusion: We concluded that lamivudine mono prophylaxis is effective in preventing de novo HBV infection in recipients receiving grafts from anti-HBc positive donors. © H.G.E. Update Medical Publishing S.A.