Objective: Primary implant stability during early healing ensures successful osseointegration. Platelet-rich fibrin (PRF) is frequently used to accelerate soft and hard tissue healing. The aim of this study is to evaluate the effect of platelet-rich fibrin(PRF) on osseointegration by resonance frequency analysis (RFA) on early and long term healing periods. In addition the influence of PRF on creastal bone resorption was investigated radiographically.

Materials and methods: In this study 24 healthy patients with adequate alveolar bone and one or more adjacent missing teeth extracted at least 6 months previously were included. After surgical preparation of the implant sockets, buffy coat parts of PRF which was prepared preoperatively was placed (Test group PRF+). Remaining part of PRF had been used to cover the crestal bones. Standard implant surgical procedure was followed with the control group (PRF-). Resonance frequency measurements were made by OsstellTM mentor intraoperatively and on the post-operative 1.,2.,3.,4.,6.,8. and the following 12.weeks. For all patients, dental panoramic radiographs were made before surgery, immediately after surgery and one year after.

Results: RFA value demonstrated that, there was not statisically significant difference between the stability measurements of PRF+ and PRF- group on early and long healing period. (p>0.05) Moreover, it was shown that, there was not statistically significant difference between radiographic measurements of PRF+ and PRF- group on crestal bone resorption at one year follow up. (p>0.05)

Conclusion: As a result, it shows that PRF application around the implant socket does not have a positive effect on short and long term RFA values. In addition, it was determined that there was no extra effect on creastal bone resorption around the implant neck. Further experimantal investigations are needed to confirm these results.