Molecular Omics, cilt.20, ss.1-17, 2023 (SCI-Expanded)
Integrated multi-omics analyses of microbiomes have become increasingly
common in recent years as the emerging omics technologies provide an
unprecedented opportunity to better understand the structural and
functional properties of microbial communities. Consequently, there is a
growing need for and interest in the concepts, approaches,
considerations, and available tools for investigating diverse
environmental and host-associated microbial communities in an
integrative manner. In this review, we first provide a general overview
of each omics analysis type, including a brief history, typical
workflow, primary applications, strengths, and limitations. Then, we
inform on both experimental design and bioinformatics analysis
considerations in integrated multi-omics analyses, elaborate on the
current approaches and commonly used tools, and highlight the current
challenges. Finally, we discuss the expected key advances, emerging
trends, potential implications on various fields from human health to
biotechnology, and future directions.