Novel Hybridized Computational Paradigms Integrated with Five Stand-Alone Algorithms for Clinical Prediction of HCV Status among Patients: A Data-Driven Technique

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Madaki Z., Abacioglu N., Usman A., TANER N., Sehirli A. O., Abba S.

Life, vol.13, no.1, 2023 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 13 Issue: 1
  • Publication Date: 2023
  • Doi Number: 10.3390/life13010079
  • Journal Name: Life
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Keywords: hepatitis C status, machine learning, artificial intelligence, clinical variables, hybrid paradigms
  • Istanbul Medipol University Affiliated: Yes


The emergence of health informatics opens new opportunities and doors for different disease diagnoses. The current work proposed the implementation of five different stand-alone techniques coupled with four different novel hybridized paradigms for the clinical prediction of hepatitis C status among patients, using both sociodemographic and clinical input variables. Both the visualized and quantitative performances of the stand-alone algorithms present the capability of the Gaussian process regression (GPR), Generalized neural network (GRNN), and Interactive linear regression (ILR) over the Support Vector Regression (SVR) and Adaptive neuro-fuzzy inference system (ANFIS) models. Hence, due to the lower performance of the stand-alone algorithms at a certain point, four different novel hybrid data intelligent algorithms were proposed, including: interactive linear regression-Gaussian process regression (ILR-GPR), interactive linear regression-generalized neural network (ILR-GRNN), interactive linear regression-Support Vector Regression (ILR-SVR), and interactive linear regression-adaptive neuro-fuzzy inference system (ILR-ANFIS), to boost the prediction accuracy of the stand-alone techniques in the clinical prediction of hepatitis C among patients. Based on the quantitative prediction skills presented by the novel hybridized paradigms, the proposed techniques were able to enhance the performance efficiency of the single paradigms up to 44% and 45% in the calibration and validation phases, respectively.