The Long Term Results of Hyaluronic Acid/Dextranomer Injection Laryngoplasty in Unilateral Vocal Fold Paralysis

Alaskarov E., Batıoğlu-Karaaltın A., Erdur Z. B., GÜLMEZ Z. D., İnan H. C., Öztürk Ö.

Annals of Otology, Rhinology and Laryngology, vol.133, no.5, pp.524-531, 2024 (SCI-Expanded) identifier identifier

  • Publication Type: Article / Article
  • Volume: 133 Issue: 5
  • Publication Date: 2024
  • Doi Number: 10.1177/00034894241232478
  • Journal Name: Annals of Otology, Rhinology and Laryngology
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, BIOSIS, CAB Abstracts, CINAHL, EMBASE, Linguistics & Language Behavior Abstracts, MLA - Modern Language Association Database, Veterinary Science Database
  • Page Numbers: pp.524-531
  • Keywords: hyaluronic acid, hyaluronic acid/dextranomer, swallowing, vocal fold paralysis, voice
  • Istanbul Medipol University Affiliated: No


Objective: This study was conducted to present the long-term functional outcomes of injection laryngoplasty (IL) with hyaluronic acid/dextranomer (HA/D) in unilateral vocal fold paralysis (UVFP). Methods: A total of 40 patients who underwent HA/D injection for UVFP were enrolled. The acoustic analysis of the voice was evaluated with jitter percentage, shimmer percentage, maximum phonation time, harmonics-to-noise ratio, and fundamental frequency. The psychosocial effect of the voice was determined using the Voice Handicap Index-10. Fiberoptic endoscopic evaluation of swallowing was performed and 2 scales were used for quantification: a modified penetration-aspiration scale and a dysphagia score. All measurements were performed at preoperative day and postoperative months 1, 6, and 24. Results: A statistically significant improvement was observed for all of the evaluated parameters except the maximum phonation time for postoperative months 1, 6, and 24 (P <.05). In the evaluation of the maximum phonation time, although there was a significant improvement for the postoperative months 1 and 6, no significant difference was observed between the postoperative 24th month and the preoperative value. Conclusions: HA/D injection laryngoplasty is an effective method both in the short- and long-term to improve voice and swallowing functions in patients with UVFP.