Effect of three different remineralizing agents on artificial erosive lesions of primary teeth


Australian Dental Journal, vol.67, no.3, pp.271-280, 2022 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 67 Issue: 3
  • Publication Date: 2022
  • Doi Number: 10.1111/adj.12922
  • Journal Name: Australian Dental Journal
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, CAB Abstracts, CINAHL, EMBASE, MEDLINE
  • Page Numbers: pp.271-280
  • Keywords: Erosive lesion, in vitro, primary teeth, self-assembling peptide, tooth remineralization
  • Istanbul Medipol University Affiliated: Yes


Background: This study aimed to investigate the efficacy of three remineralizing agents on dental erosion in primary teeth. Methods: Forty primary molars were randomly divided into four groups (n = 10 each): self-assembling peptide (P11–4), casein phosphopeptide-amorphous calcium fluoride phosphate (CPP-ACFP), sodium fluoride (NaF) and artificial saliva (AS; control). The erosion-like formation was created by immersing the samples in citric acid (4 × 2 min, pH 2.3) and AS (4 × 2 h, pH 7). The eroded samples were then treated with remineralizing agents and subjected to further erosion consisting of 15 cycles (3x/8-h interval) of immersion in citric acid and AS for 6 s each. Alterations in the mineral content and morphology of the samples were quantified using a microhardness tester and atomic force microscope. Results: All agents had a significant remineralization effect on eroded primary tooth enamel. After further erosive challenge, enamel loss in the CPP-ACFP group was found to be significantly lower than in all other groups, and no significant difference was found between the P11–4 and NaF groups. Conclusions: This study showed that all tested materials had remineralization ability, and CPP-ACFP had a superior effect in inhibiting enamel loss due to dental erosion in primary teeth. © 2022 Australian Dental Association.