Hypertension in 2017: Update in treatment and pharmaceutical innovations

Okur M. E., Karantas I. D., Okur N. Ü., Siafaka P. I.

Current Pharmaceutical Design, vol.23, no.44, pp.6759-6814, 2017 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Review
  • Volume: 23 Issue: 44
  • Publication Date: 2017
  • Doi Number: 10.2174/1381612823666170927123454
  • Journal Name: Current Pharmaceutical Design
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.6759-6814
  • Keywords: Hypertension, new antihypertensive formulations, epidemiology, Mediterranean countries, guidelines, treatment
  • Istanbul Medipol University Affiliated: Yes


Hypertension can be referred to as modern scourge in 2017 and although, it seems that an improvement has been done during the passage of time, the full treatment still remains an unmet achievement for clinicians. Hypertension incidence in Mediterranean countries, especially Greece and Turkey, seems to be increasing irrespective of the expected protective effect of Mediterranean diet. The changed lifestyle and dietary habits of both populations led to advanced cardiovascular events and arteriosclerosis both of which are linked with high blood pressure. From statistic aspect, as in this work reviewed, it has been found out that gender, age, sociodemographic characteristics and geographical location could promote the hypertension prevalence. Given the above, as well as the fact that the current pharmaceutical formulations do not present the optimal results on hypertension management, summing up the ongoing research on hypertension field is in high demand. Consequently, the development of novel solutions for high blood pressure management either with new synthesized drugs or fascinated drug delivery systems is required. Moreover, adopting healthy lifestyle and diet also plays a crucial role against hypertension. This review is aimed at assisting researchers working on hypertension management by summarizing update guidelines, various case reports describing hypertension related with other diseases, current medications and newly synthesized drug delivery systems recently found in literature.