Dose-dependent neuroprotective effect of enoxaparin on cold-induced traumatic brain injury
Neural Regeneration Research, cilt.12, sa.5, ss.761-764, 2017 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 12 Sayı: 5
- Basım Tarihi: 2017
- Doi Numarası: 10.4103/1673-5374.206646
- Dergi Adı: Neural Regeneration Research
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Sayfa Sayıları: ss.761-764
- Anahtar Kelimeler: nerve regeneration, neuroprotection, traumatic brain injury, cold-induced brain injury, enoxaparin, anti-oxidative, apoptosis, neural regeneration
- İstanbul Medipol Üniversitesi Adresli: Evet
Özet
Recent evidence exists that enoxaparin can reduce brain injury because of its anticoagulant activity. To investigate the potential therapeutic effect of enoxaparin on cold-induced traumatic brain injury, at 20 minutes after modeling, male BALB/c mouse models of cold-induced traumatic brain injury were intraperitoneally administered 3 and 10 mg/kg enoxaparin or isotonic saline solution. Twenty-four hours later, enoxaparin at 10 mg/kg greatly reduced infarct volume, decreased cell apoptosis in the cortex and obviously increased serum level of total antioxidant status. By contrast, administration of enoxaparin at 3 mg/kg did not lead to these changes. These findings suggest that enoxaparin exhibits neuroprotective effect on cold-induced traumatic brain injury in a dose-dependent manner.