Dose-dependent neuroprotective effect of enoxaparin on cold-induced traumatic brain injury

KESKİN İ., Gunal M. Y., Ayturk N., Kilic U., Ozansoy M., Kilic E.

Neural Regeneration Research, vol.12, no.5, pp.761-764, 2017 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 12 Issue: 5
  • Publication Date: 2017
  • Doi Number: 10.4103/1673-5374.206646
  • Journal Name: Neural Regeneration Research
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.761-764
  • Keywords: nerve regeneration, neuroprotection, traumatic brain injury, cold-induced brain injury, enoxaparin, anti-oxidative, apoptosis, neural regeneration
  • Istanbul Medipol University Affiliated: Yes


Recent evidence exists that enoxaparin can reduce brain injury because of its anticoagulant activity. To investigate the potential therapeutic effect of enoxaparin on cold-induced traumatic brain injury, at 20 minutes after modeling, male BALB/c mouse models of cold-induced traumatic brain injury were intraperitoneally administered 3 and 10 mg/kg enoxaparin or isotonic saline solution. Twenty-four hours later, enoxaparin at 10 mg/kg greatly reduced infarct volume, decreased cell apoptosis in the cortex and obviously increased serum level of total antioxidant status. By contrast, administration of enoxaparin at 3 mg/kg did not lead to these changes. These findings suggest that enoxaparin exhibits neuroprotective effect on cold-induced traumatic brain injury in a dose-dependent manner.