Relationship between interleukin 33 and tissue factor in non-diabetic and diabetic obese patients

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ÇAKICI Ç., YİĞİTBAŞI T., Alagoz M. H., YİĞİT P., Eme-Kli N.

Acta Pharmaceutica Sciencia, vol.59, no.4, pp.559-573, 2021 (Scopus) identifier

  • Publication Type: Article / Article
  • Volume: 59 Issue: 4
  • Publication Date: 2021
  • Doi Number: 10.23893/1307-2080.aps.05934
  • Journal Name: Acta Pharmaceutica Sciencia
  • Journal Indexes: Scopus, EMBASE
  • Page Numbers: pp.559-573
  • Keywords: Diabetes Mellitus, Interleukin 33, Obesity, Tissue factor
  • Istanbul Medipol University Affiliated: Yes


The aim of the study is to investigate the relationship between tissue factor (TF) and Interleukin-33 (IL-33) and biochemical parameters in diabetic obese and non-diabetic obese patients. 21 healthy controls, 25 non-diabetic and 36 diabetic-obese patients were included in the study. While there was no difference between the groups in terms of IL-33 levels (p> 0.05), TF levels of diabetic obese group were statistically significantly higher than control group (p <0.05). HDL levels of the obese and diabetic obese groups were significantly lower than control group, and triglyceride, glucose, insulin, C-reactive protein (CRP), hemoglobin A1c (HbA1c), and HOMA-IR levels were significantly higher (p <0.05). A positive correlation was found between TF activity, and HbA1c and glucose levels (p <0.05). This suggests that TF may be predictive for diabetes which develop in the background of obesity, and that TF can be used as a prognostic value for diabetes.