Effect of oral use of various edible oils on wound healing in rats: randomized controlled experimental study

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Cakmak Kafadar G., BÜYÜKUSLU N., KOLBAŞI B., KESKİN İ., Mercan Y.

Acta Pharmaceutica Sciencia, vol.60, no.2, pp.179-201, 2022 (Scopus) identifier

  • Publication Type: Article / Article
  • Volume: 60 Issue: 2
  • Publication Date: 2022
  • Doi Number: 10.23893/1307-2080.aps.6013
  • Journal Name: Acta Pharmaceutica Sciencia
  • Journal Indexes: Scopus, EMBASE
  • Page Numbers: pp.179-201
  • Keywords: black cumin oil, Hypericum perforatum olive oil extract, olive oil, sesame oil, sunflower oil, wound healing
  • Istanbul Medipol University Affiliated: Yes


There are various studies showing that oral supplements are shortening or facilitat-ing effects on this process. Therefore, this study investigates the use of edible oils as supplements in the wound healing process. Of the 7 groups (control, Hypericum perforatum extracts in olive oil, olive, sesame, fish, black seed, sunflower), each has 8 Wistar Albino rats. In the experimental groups, 1.25 mL/kg oral oil was used for 10 days. Macroscopic images of the wound area were taken. Wound healing was evaluated by histological analysis. Collagen III, IL-6, TNF-α and TGF-ß1 density analyzes were performed on the tissue samples. According to macroscopic analysis, wound narrowing is higher in all groups on the 2nd and 4th days than the control group. Histopathological and immunohistochemical analyses of all experimental groups except sunflower oil group revealed better results than control group.