Glucosamine-sulfate on fracture healing Glukozamin sülfatın kırık iyileşmesine etkisi

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Uǧraş A., GÜZEL MEYDANLI E. E., KORKUSUZ P., Kaya I., Dikici F., Demirbaş E., ...More

Ulusal Travma ve Acil Cerrahi Dergisi, vol.19, no.1, pp.8-12, 2013 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 19 Issue: 1
  • Publication Date: 2013
  • Doi Number: 10.5505/tjtes.2013.03256
  • Journal Name: Ulusal Travma ve Acil Cerrahi Dergisi
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, TR DİZİN (ULAKBİM)
  • Page Numbers: pp.8-12
  • Keywords: Bone, fracture healing, glucosamine, osteoblast
  • Istanbul Medipol University Affiliated: No


BACKGROUND: The aim of this study is to determine whether glucosaminesulfate has any effects on bone-healing. METHODS: A unilateral fracture was created in the tibia of sixty-one female rats. Rats were given no drug or 230 mg/kg glucosamine- sulfate daily. Fractures were analyzed during the first, second and fourth weeks after creation of fracture. Quantitative measurement for new bone formation and osteoblast lining were determined histologically. Semiquantitative score for fracture healing was used for histomorphometric analyses. Bridging bone formation was assessed radiographically. RESULTS: New bone formation and osteoblast lining were significantly higher in glucosamine-treated group at week 1. Surrounding connective tissue was more cellular and vascular, and the newly formed bone trabecules were present in greater amounts in glucosamine-treated group, compared to control group at week 1 and 4. But radiologically, the control group had better scores than that of the glucosamine- treated group at week 4. CONCLUSION: These data demonstrate that daily glucosamine-sulfate administration accelerates early phase of fracture repair in the rat tibia, with increased new bone formation and osteoblast lining histologically, but radiologic bone union is not favored on radiographs.