Synthesis and cytotoxicity studies of novel benzhydrylpiperazine carboxamide and thioamide derivatives

Gurdal E. E., Durmaz I., Cetin-Atalay R., Yarim M.

Journal of Enzyme Inhibition and Medicinal Chemistry, vol.29, no.2, pp.205-214, 2014 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 29 Issue: 2
  • Publication Date: 2014
  • Doi Number: 10.3109/14756366.2013.765416
  • Journal Name: Journal of Enzyme Inhibition and Medicinal Chemistry
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.205-214
  • Keywords: Benzhydrylpiperazine, cytotoxicity, isocyanate, isothiocyanate, sulphorhodamine B
  • Istanbul Medipol University Affiliated: No

Abstract

Synthesis and cytotoxic activities of 32 benzhydrylpiperazine derivatives with carboxamide and thioamide moieties were reported. In vitro cytotoxic activities of compounds were screened against hepatocellular (HUH-7), breast (MCF-7) and colorectal (HCT-116) cancer cell lines by sulphorhodamine B assay. In general, 4-chlorobenzhydrylpiperazine derivatives were more cytotoxic than other compounds. In addition, thioamide derivatives (6a-g) have higher growth inhibition than their carboxamide analogs. © 2014 Informa UK Ltd. All rights reserved.