Synthesis and cytotoxicity studies of novel benzhydrylpiperazine carboxamide and thioamide derivatives

Gurdal E. E., Durmaz I., Cetin-Atalay R., Yarim M.

Journal of Enzyme Inhibition and Medicinal Chemistry, cilt.29, sa.2, ss.205-214, 2014 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 29 Sayı: 2
  • Basım Tarihi: 2014
  • Doi Numarası: 10.3109/14756366.2013.765416
  • Dergi Adı: Journal of Enzyme Inhibition and Medicinal Chemistry
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.205-214
  • Anahtar Kelimeler: Benzhydrylpiperazine, cytotoxicity, isocyanate, isothiocyanate, sulphorhodamine B
  • İstanbul Medipol Üniversitesi Adresli: Hayır

Özet

Synthesis and cytotoxic activities of 32 benzhydrylpiperazine derivatives with carboxamide and thioamide moieties were reported. In vitro cytotoxic activities of compounds were screened against hepatocellular (HUH-7), breast (MCF-7) and colorectal (HCT-116) cancer cell lines by sulphorhodamine B assay. In general, 4-chlorobenzhydrylpiperazine derivatives were more cytotoxic than other compounds. In addition, thioamide derivatives (6a-g) have higher growth inhibition than their carboxamide analogs. © 2014 Informa UK Ltd. All rights reserved.