Cytotoxic activity of the fruit extracts of Heptaptera anatolica (Boiss.) Tutin

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TOSUN F., MİSKİ M.

Acta Pharmaceutica Sciencia, vol.60, no.2, pp.125-129, 2022 (Scopus) identifier

  • Publication Type: Article / Article
  • Volume: 60 Issue: 2
  • Publication Date: 2022
  • Doi Number: 10.23893/1307-2080.aps.6009
  • Journal Name: Acta Pharmaceutica Sciencia
  • Journal Indexes: Scopus, EMBASE
  • Page Numbers: pp.125-129
  • Keywords: Apiaceae, Cytotoxic activity, Heptaptera anatolica
  • Istanbul Medipol University Affiliated: Yes

Abstract

Cytotoxic activities of the fruit extracts of Heptaptera anatolica (Boiss.) Tutin were investigated on the colon cancer COLO205 and KM12 cell lines. The dichlorometh-ane extract of the fruits of H. anatolica showed the best cytotoxic activities with IC50 values of 17.9 and 15.1 ug/mL on the COLO205 and KM12 cell lines, respectively. Whereas, the ethyl acetate extract of the fruits showed moderate cytotoxic activity with IC50 values of 23.4 ug/mL against the KM12 cell lines.