Hepatoprotective effect of Foeniculum vulgare essential oil

Özbek H., Uǧraş S., Dülger H., Bayram I., Tuncer I., ÖZTÜRK G., ...More

Fitoterapia, vol.74, no.3, pp.317-319, 2003 (SCI-Expanded) identifier identifier

  • Publication Type: Article / Article
  • Volume: 74 Issue: 3
  • Publication Date: 2003
  • Doi Number: 10.1016/s0367-326x(03)00028-5
  • Journal Name: Fitoterapia
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.317-319
  • Keywords: Fennel essential oil, Foeniculum vulgare, Hepatoprotective effect
  • Istanbul Medipol University Affiliated: Yes


Hepatoprotective activity of Foeniculum vulgare (fennel) essential oil (FEO) was studied using carbon tetrachloride (CCl4) induced liver injury model in rats. The hepatotoxicity produced by acute CCl4 administration was found to be inhibited by FEO with evidence of decreased levels of serum aspartate aminotransferase (AST), alanine aminotransferase (ALT), alkaline phosphatase (ALP) and bilirubin. The results of this study indicate that FEO has a potent hepatoprotective action against CCl4-induced hepatic damage in rats. © 2003 Elsevier Science B.V. All rights reserved.