Anti-allergic effects of vitamin E in allergic diseases: An updated review

Shams M., Jafari R., Eskandari N., Masjedi M., Kheirandish F., Ganjalikhani Hakemi M., ...More

International Immunopharmacology, vol.90, 2021 (SCI-Expanded) identifier identifier

  • Publication Type: Article / Review
  • Volume: 90
  • Publication Date: 2021
  • Doi Number: 10.1016/j.intimp.2020.107196
  • Journal Name: International Immunopharmacology
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, BIOSIS, Biotechnology Research Abstracts, CAB Abstracts, Chemical Abstracts Core, EMBASE, MEDLINE, Veterinary Science Database
  • Keywords: Allergic rhinitis, Antioxidant, Asthma, Atopic dermatitis, Food allergy, Vitamin E
  • Istanbul Medipol University Affiliated: No


Allergic diseases are caused by the immune system's response to innocent antigens called allergens. Recent decades have seen a significant increase in the prevalence of allergic diseases worldwide, which has imposed various socio-economic effects in different countries. Various factors, including genetic factors, industrialization, improved hygiene, and climate change contribute to the development of allergic diseases in many parts of the world. Moreover, changes in lifestyle and diet habits play pivotal roles in the prevalence of allergic diseases. Dietary changes caused by decreased intake of antioxidants such as vitamin E lead to the generation of oxidative stress, which is central to the development of allergic diseases. It has been reported in many articles that oxidative stress diverts immune responses to the cells associated with the pathogenesis of allergic diseases. The aim of this short review was to summarize current knowledge about the anti-allergic properties of vitamin E.