The effect of zinc and melatonin supplementation on immunity parameters in breast cancer induced by DMBA in rats

Baltaci S. B., Mogulkoc R., Baltaci A. K., Emsen A., Artac H.

Archives of Physiology and Biochemistry, vol.124, no.3, pp.247-252, 2018 (SCI-Expanded) identifier identifier

  • Publication Type: Article / Article
  • Volume: 124 Issue: 3
  • Publication Date: 2018
  • Doi Number: 10.1080/13813455.2017.1392580
  • Journal Name: Archives of Physiology and Biochemistry
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.247-252
  • Keywords: Cancer, DMBA, immunity, melatonin, zinc
  • Istanbul Medipol University Affiliated: No


Objective: The aim of the study was to determine the effects of zinc and melatonin supplements on the immunity parameters of female rats with breast cancer induced by DMBA. Methods: Group 1; Control, Group 2; 7,12-dimethylbenz[a]anthracene (DMBA), Group 3; DMBA + zinc, Group 4; DMBA + melatonin, Group 5; DMBA + zinc + melatonin. The rats’ breast cancer was induced by DMBA 80 mg/kg. Groups 3–5 received daily 5 mg/kg doses of zinc, melatonin, and zinc + melatonin, respectively. Lymphocyte rates, T-lymphocyte subgroups, B-lymphocyte and natural killer cells (NK), and natural killer T (NKT) were evaluated. Results: The most significant increase in lymphocyte, T-lymphocyte, and CD4 lymphocyte rates was found in Group 5. The highest NKT cell rates were found in Group 3. Conclusions: Findings show that zinc and melatonin supplements have led to an increase in the immunity parameters of rats with breast cancer.