The effect of zinc and melatonin supplementation on immunity parameters in breast cancer induced by DMBA in rats

Baltaci S. B., Mogulkoc R., Baltaci A. K., Emsen A., Artac H.

Archives of Physiology and Biochemistry, cilt.124, sa.3, ss.247-252, 2018 (SCI-Expanded) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 124 Sayı: 3
  • Basım Tarihi: 2018
  • Doi Numarası: 10.1080/13813455.2017.1392580
  • Dergi Adı: Archives of Physiology and Biochemistry
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.247-252
  • Anahtar Kelimeler: Cancer, DMBA, immunity, melatonin, zinc
  • İstanbul Medipol Üniversitesi Adresli: Hayır

Özet

Objective: The aim of the study was to determine the effects of zinc and melatonin supplements on the immunity parameters of female rats with breast cancer induced by DMBA. Methods: Group 1; Control, Group 2; 7,12-dimethylbenz[a]anthracene (DMBA), Group 3; DMBA + zinc, Group 4; DMBA + melatonin, Group 5; DMBA + zinc + melatonin. The rats’ breast cancer was induced by DMBA 80 mg/kg. Groups 3–5 received daily 5 mg/kg doses of zinc, melatonin, and zinc + melatonin, respectively. Lymphocyte rates, T-lymphocyte subgroups, B-lymphocyte and natural killer cells (NK), and natural killer T (NKT) were evaluated. Results: The most significant increase in lymphocyte, T-lymphocyte, and CD4 lymphocyte rates was found in Group 5. The highest NKT cell rates were found in Group 3. Conclusions: Findings show that zinc and melatonin supplements have led to an increase in the immunity parameters of rats with breast cancer.