Cutting edge: Metabolic immune reprogramming, reactive oxygen species, and cancer

Aria H., Ghaedrahmati F., Ganjalikhani-Hakemi M.

Journal of Cellular Physiology, vol.236, no.9, pp.6168-6189, 2021 (SCI-Expanded) identifier identifier

  • Publication Type: Article / Review
  • Volume: 236 Issue: 9
  • Publication Date: 2021
  • Doi Number: 10.1002/jcp.30303
  • Journal Name: Journal of Cellular Physiology
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, BIOSIS, CAB Abstracts, Chemical Abstracts Core, EMBASE, MEDLINE, Veterinary Science Database
  • Page Numbers: pp.6168-6189
  • Keywords: immunometabolism, metabolic reprogramming, reactive oxygen species, T cells, tumor cells
  • Istanbul Medipol University Affiliated: No


A recently proposed term “immunometabolism” points to the functional intracellular metabolic changes that occur within different immune cells. Recent findings suggest that immune responses can be determined by the metabolic status of immune cells and metabolic reprogramming is an important feature of immune cell activation. Metabolic reprogramming is also well known for cancer cells and has been suggested as a major sign of cancer progression. Metabolic reprogramming of immune cells is also seen in the tumor microenvironment. In the past decade, immunometabolism has progressively become an extraordinarily vibrant and productive area of study in immunology because of its importance for immunotherapy. Understanding the immunometabolic situation of T cells and other immune cells along with the metabolic behavior of cancer cells can help us design new therapeutic approaches against cancers. Here, we have the aim to review the cutting-edge findings on the immunometabolic situation in immune and tumor cells. We discuss new findings on signaling pathways during metabolic reprogramming, its regulation, and the participation of reactive oxygen species in these processes.