A rare gestational trophoblastic neoplasia form; Placental site trophoblastic tumor and literature review Nadır görülen bır gestasyonel trofoblastık neoplazı formu; Plasental sıte trofoblastık tümör ve lıteratürün gözden geçırılmesı

Aktün L. H., Yorgunlar B., Naki M., Özdemir S., Köse F.

Turk Jinekolojik Onkoloji Dergisi, vol.18, no.3, pp.104-107, 2015 (Scopus) identifier

  • Publication Type: Article / Review
  • Volume: 18 Issue: 3
  • Publication Date: 2015
  • Journal Name: Turk Jinekolojik Onkoloji Dergisi
  • Journal Indexes: Scopus
  • Page Numbers: pp.104-107
  • Keywords: Gestational trophoblastic neoplasia, Trophoblastic tumor
  • Istanbul Medipol University Affiliated: Yes


Placental site trophoblastic tumor (PSTT) is one of the gestational trophoblastic neoplasias (GTN) arising from intermediate gestational trophoblasts. It is a rarely seen type of GTN’s, and 300 cases have been reported in the literature so far (1). Is also covers 1-2%of trophoblastic tumors (2). Having a low incidence limits the understanding of its etiology and clinical pathology. Typically seen in women of reproductive age and term pregnancy may occur months or years later. It may occur after any pregnancy as well. PTTY is not easy to diagnose in the early stages because patients often present with irregular vaginal bleeding or amenorrhea. β-HCG levels are generally lower than those patients moderately high and choriocarcinoma (3). Infiltration of the proliferative growth myometrial muscle in the intermediate trophoblast is required for diagnosis. İntrauterine aspiration is inadequate and uterine curettage is required for diagnosis. While GTNs are responsive to chemotherapy, PSTTs are relatively chemoresistance due to the weak biological behavior (3). PSTT grows slowly, spreads into the uterus, and makes metastatis passing to lymph nodes. Hysterectomy is the most effective treatment to the non-metastatic disease (3). For metastatic patients and with high mitotic indexed large tumor adjuvant chemotherapy is recommended. We aim to provide a PSTT which is a rare form of GTNs’case accompanying the literature in the case report.