The efficacy of fluoxetine in the treatment of premature ejaculation: A double-blind placebo controlled study

Kara H., Aydin S., Aǧargün M. Y., Odabaş Ö., Yilmaz Y.

Journal of Urology, vol.156, no.5, pp.1631-1632, 1996 (Scopus) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 156 Issue: 5
  • Publication Date: 1996
  • Doi Number: 10.1016/s0022-5347(01)65467-3
  • Journal Name: Journal of Urology
  • Journal Indexes: Scopus
  • Page Numbers: pp.1631-1632
  • Keywords: fluoxetine, ejaculation, psychosexual dysfunctions
  • Istanbul Medipol University Affiliated: No


Purpose: The efficacy of the selective serotonin re-uptake inhibitor fluoxetine in the treatment of premature ejaculation was examined. Materials and Methods: The study comprised 17 patients with premature ejaculation who presented to the urology clinic of our medical school. In this double-blind study the patients were randomized into treatment groups receiving 20 mg. fluoxetine daily for 1 week and 40 mg. daily afterward (group 1) or 1 capsule placebo daily for i week and 2 capsules daily afterward (group 2). The groups were evaluated according to the latent period of intravaginal ejaculation. Results: The latent period of intravaginal ejaculation in group 1 was significantly longer than that in group 2. Nausea, headache and insomnia were reported side effects. Conclusions: Fluoxetine may be regarded as a safe and effective alternative in the treatment of premature ejaculation.