Chemical and metabolic studies on N-benzyl-tert-butylamine and its potential metabolites

Ulgen M., Yilmaz F., Unsalan S., Gorrod J. W.

Drug Metabolism and Drug Interactions, cilt.12, sa.2, ss.131-144, 1995 (Scopus) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 12 Sayı: 2
  • Basım Tarihi: 1995
  • Doi Numarası: 10.1515/dmdi.1995.12.2.131
  • Dergi Adı: Drug Metabolism and Drug Interactions
  • Derginin Tarandığı İndeksler: Scopus
  • Sayfa Sayıları: ss.131-144
  • Anahtar Kelimeler: hamster, metabolism, microsomes, N-benzyl-tert-butylamine, nitrones, oxaziridines
  • İstanbul Medipol Üniversitesi Adresli: Hayır

Özet

The metabolism of N-benzyl-tert-butylamine was studied in vitro using male hamster hepatic microsomal preparations. This substrate produced the corresponding nitrone, benzaldehyde and an uncharacterised metabolite. No metabolites were detected which corresponded to either authentic amide or oxaziridine. The results indicate that the nitrone observed as a metabolite in this experiment is not an intermediate leading to the formation of an oxaziridine and hence an amide, under careful experimental conditions excluding light. © Freund Publishing House, Ltd. 1995