Anti-inflammatory and hypoglycemic activities of alpha-pinene

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Acta Pharmaceutica Sciencia, vol.55, no.4, pp.7-14, 2017 (Scopus) identifier

  • Publication Type: Article / Article
  • Volume: 55 Issue: 4
  • Publication Date: 2017
  • Doi Number: 10.23893/1307-2080.aps.05522
  • Journal Name: Acta Pharmaceutica Sciencia
  • Journal Indexes: Scopus
  • Page Numbers: pp.7-14
  • Keywords: Alpha-pinene, Anti-inflammatory activity, Hypoglycemic activity, Mice, Rats
  • Istanbul Medipol University Affiliated: Yes


The aim of this study is to investigate the anti-inflammatory and hypoglycemic activities of alpha-pinene, and to find the median lethal dose (LD50) level in mice. Lethal dose levels of alpha-pinene were investigated using a probit analysis method. For the anti-inflammatory activity measurement seven different groups were established and alpha-pinene was administered in four different doses: 0.05, 0.10, 0.25 and 0.50 mL/kg. For the evaluation of hypoglycemic activity six different groups, consisting of diabetic and healthy mice, were established. The strongest anti-inflammatory activity of alpha-pinene was observed with a 0.50 mL/kg dosage. The median effective dose (ED50) value of alpha-pinene was found to be 0.039 mL/kg. In diabetic mice α-pinene showed significant levels of hypoglycemic activity at the 2nd and 24th hours. LD50 level of α-pinene was determined to be 2.076 mL/kg. As a result, we conclude that alpha-pinene is a molecule that displays hypoglycemic and anti-inflammatory activities.