Atıf İçin Kopyala
Gurdal E. E., Durmaz I., Cetin-Atalay R., Yarim M.
Journal of Enzyme Inhibition and Medicinal Chemistry, cilt.30, sa.4, ss.649-654, 2015 (SCI-Expanded)
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Yayın Türü:
Makale / Tam Makale
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Cilt numarası:
30
Sayı:
4
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Basım Tarihi:
2015
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Doi Numarası:
10.3109/14756366.2014.959513
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Dergi Adı:
Journal of Enzyme Inhibition and Medicinal Chemistry
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Derginin Tarandığı İndeksler:
Science Citation Index Expanded (SCI-EXPANDED), Scopus
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Sayfa Sayıları:
ss.649-654
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Anahtar Kelimeler:
Anticancer, benzothiazole, cytotoxicity, piperazine, sulphorodamine B
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İstanbul Medipol Üniversitesi Adresli:
Hayır
Özet
Synthesis, characterization and cytotoxic activities of ten benzothiazole-piperazine derivatives were reported. In vitro cytotoxic activities of compounds were screened against hepatocellular (HUH-7), breast (MCF-7) and colorectal (HCT-116) cancer cell lines by sulphorhodamine B assay. Based on the GI50 values of the compounds, most of the benzothiazole-piperazine derivatives are active against HUH-7, MCF-7 and HCT-116 cancer cell lines. Compound 1d is highly cytotoxic against all tested cancer cell lines. Further investigation of compound 1d by Hoechst Staining and Fluorescence-Activated Cell Sorting Analysis (FACS) revealed that this compound causes apoptosis by cell cycle arrest at subG1 phase.