Akademik Veri Yönetim Sistemi
FLORA INFEKSIYON HASTALIKLARI VE KLINIK MIKROBIYOLOJI DERGISI, cilt.29, sa.4, ss.509-515, 2024 (ESCI, TRDizin)
Introduction: Infective endocarditis (IE) remains an important infectious disease with a high mortality rate despite advancements in diagnostic and therapeutic methods. Our study aimed to determine the demographic characteristics, clinical, microbiologic, and imaging findings, treatment modalities and clinical outcomes, and factors affecting mortality in IE cases. Materials and Methods: The study was retrospectively designed in a tertiary university hospital. Between January 2015 and December 2023, 64 cases of definite and probable IE in individuals over the age of 18, defined according to the 2023 Duke IE criteria by The International Society for Cardiovascular Infectious Diseases, were included in the study. Results: The median age was 61.5 years (interquartile range= 48-74 years) and 69% (n= 44) were male. The most common symptoms and signs were fever (84.3%), murmur (62.5%), and embolic events (25%). Definite IE was diagnosed in 91% (n= 58) and probable IE in 9% (n= 6) of the patients. Natural valve IE was identified in 51.6% of cases, prosthetic valve IE in 34.4%, and pacemaker IE in 14%. The most commonly affected valves were mitral (35.6%) and aortic (33.3%) valves. Microbiological diagnostic methods identified the causative agent in 89.1% of cases. The most frequently isolated microorganisms were staphylococci (43.8%) and enterococci (21.9%). Surgery was performed in 50% of the patients. The mortality rate during hospitalization was 22%. Higher mortality rates were observed in the presence of advanced age, coronary artery disease, chronic kidney disease, and pacemaker endocarditis. Conclusion: It is noteworthy that the average age of patients with IE is increasing, staphylococci are the predominant microbiological agent, and patients with endocarditis associated with advanced age, chronic kidney disease, and the presence of a pacemaker have a more severe prognosis. These findings emphasize the critical importance of IE management being conducted by an IE team, as recommended in the European Society of Cardiology 2023 endocarditis guidelines.