Reconfigurable hardware-based genome aligner using quality scores Yeniden yapilandirilabilir donanim tabanli kalite degerlerini kullanan genom hizalayic
2013 21st Signal Processing and Communications Applications Conference, SIU 2013, Haspolat, Türkiye, 24 - 26 Nisan 2013, (Tam Metin Bildiri)
- Yayın Türü: Bildiri / Tam Metin Bildiri
- Doi Numarası: 10.1109/siu.2013.6531567
- Basıldığı Şehir: Haspolat
- Basıldığı Ülke: Türkiye
- Anahtar Kelimeler: Alignment, Bioinformatics, Field progmammable gate array, Hardware alignment quality scores
- İstanbul Medipol Üniversitesi Adresli: Hayır
Özet
Smith Waterman Algorithm is a widely used tool in bioinformatics to align reads from aligning to a reference in whole genome sequencing. Mapping millions of sequences read from sequencing is a computationally expensive operation. Accuracy and performance are two important aspects of this process. FPGA based solutions are widely studied. In this paper we tried to achieve a better mapping accuracy for optimum alignment using quality scores of the bases of read sequences while keeping the performance high. We are offering a new Smith Waterman processing unit and systolic array based on quality scores. © 2013 IEEE.