In vitro ACE2 Enzyme Inhibitory Activity Evaluation of Different Salvia Essential Oils

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Acta Pharmaceutica Sciencia, vol.60, no.2, pp.117-124, 2022 (Scopus) identifier

  • Publication Type: Article / Article
  • Volume: 60 Issue: 2
  • Publication Date: 2022
  • Doi Number: 10.23893/1307-2080.aps.6008
  • Journal Name: Acta Pharmaceutica Sciencia
  • Journal Indexes: Scopus, EMBASE
  • Page Numbers: pp.117-124
  • Keywords: ACE2, coronavirus, essential oil, Salvia
  • Istanbul Medipol University Affiliated: Yes


In this present study, commertially available Salvia triloba L., S.officinalis L., and S. sclarea L. essential oils were evaluated for their in vitro angiotensin converting enzyme 2 (ACE2) inhibitory activity. The Salvia essential oils compositions were confirmed both by GC-FID and GC/MS. Main components of the S. triloba essential oil was characterized as 1,8-cineole (22.8%), camphor (17.2%), α-thujone (15.2 %), β-caryophyllene (11.4 %), and α-humulene (3%). Major constiutents were identified as α-thujone (28.5 %), camphor (20.6 %), 1,8-cineole (10.9%), α-humulene (5%), and camphene (4.9 %) in S. officinalis essential oil. Whereas, linalylacetate (56.8 %), linalool (21.1%), α-terpineol (6.1%), geraniol (5%), and β-caryophyllene (3.4%) were the major components of S. sclarea essential oil. The essential oils were evaluated using a fluorometric multiplate based enzyme inhibition kit, where the ACE2 inhi-bitions of S. triloba, S. officinalis, and S. sclarea essential oils were 50.1%, 60.5%, and 72.1% at a concentration of 20 µg/mL, respectively. As a result, further tests of Salvia essential oils supported by in vivo studies may have antiviral potential ap-plications against coronaviruses due to ACE2 enzyme inhibitions.