Six-Minute Walk Performance and Related Factors in Pediatric-Onset Multiple Sclerosis

ZENGİNLER YAZGAN Y., Vural P., Ormen R., Akinci B., TARAKCI E., GÜLER S., ...More

Journal of Child Neurology, vol.37, no.5, pp.351-358, 2022 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 37 Issue: 5
  • Publication Date: 2022
  • Doi Number: 10.1177/08830738211072701
  • Journal Name: Journal of Child Neurology
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, BIOSIS, CAB Abstracts, EBSCO Education Source, EMBASE, MEDLINE, MLA - Modern Language Association Database, Psycinfo
  • Page Numbers: pp.351-358
  • Keywords: six-minute walk test, pediatric-onset multiple sclerosis, functional exercise capacity, physical activity, balance
  • Istanbul Medipol University Affiliated: No


Objective: To investigate functional exercise capacity and its relationship between physical activity levels, muscle strength, balance, fatigue, and quality of life in patients with pediatric-onset multiple sclerosis. Methods: Fifteen patients with pediatric-onset multiple sclerosis were included. The 6-minute walk test was used to determine functional exercise capacity and walking distance. The Godin Leisure-Time Exercise Questionnaire and pedometer were used to evaluate physical activity, Timed-Up and Go for dynamic balance, isokinetic testing for lower extremity muscle strength, Fatigue Severity Scale for fatigue, and the Pediatric Quality of Life Inventory (PedsQL) for quality of life. Results: The 6-minute walking distance was positively correlated with GLTEQ and the School-Work subgroup score of the PedsQL-Self-report, and negatively correlated with Timed-Up and Go and Fatigue Severity Scale. Dynamic balance, physical activity, and fatigue were significant predictors of 6-minute walking distance. Conclusions: Our results showed that 6-minute walk test is influenced by physical activity, dynamic balance, and fatigue, and related to quality of life in patients with pediatric-onset multiple sclerosis.