Exploring the abundance of de-oiled non-resin analgesic and anti-inflammatory compounds in Crocus sativus through polarity-directed quaternary solvent extraction in both diabetic and non-diabetic conditions: Integrating in silico and in vivo analysis
Acta Pharmaceutica Sciencia, cilt.64, sa.2, ss.181-232, 2026 (Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 64 Sayı: 2
- Basım Tarihi: 2026
- Doi Numarası: 10.23893/1307-2080.aps64012
- Dergi Adı: Acta Pharmaceutica Sciencia
- Derginin Tarandığı İndeksler: Scopus, EMBASE
- Sayfa Sayıları: ss.181-232
- Anahtar Kelimeler: analgesic, anti-inflammatory, Crocus sativus, histopathology, petal
- İstanbul Medipol Üniversitesi Adresli: Evet
Özet
Prior research indicated that the whole extract of Crocus sativus exhibited substantial analgesic and anti-inflammatory effects at a dose of 400 mg/kg. We aimed to examine the anti-inflammatory and analgesic activities of a de-oiled, non-resin fraction of C. sativus petals. The 20% n-hexane, 60% ethanol, 20% water extract of de-oiled, non-resin fraction of C. sativus was administered at 100, 200, and 400 mg/kg in rats. Study was conducted in both diabetic and non-diabetic models. The de-oiled, non-resin fraction of C. sativus petal extract imparts significant (p<0.05) anti-inflammatory and analgesic activity at a 200 mg /kg dose, both in diabetic and non-diabetic rats. So, the extract may also contain anti-diabetic compound to ameliorate diabetic condition to demonstrated identical impact both in diabetic and non-diabetic condition. It may be stated that the de-oiled, non-resin fraction of C. sativus is a potent source of analgesic and anti-inflammatory compounds in diabetic and non-diabetic conditions.