Alkaloid profiles and biological activities of different sophora jaubertii extracts Sophora jaubertiV nin Farkh Ekstrelerinin Alkaloit Profilleri ve Biyolojik Aktiviteleri

Küçükboyaci N., Adigüzel N., Özkan S., TOSUN F.

Turkish Journal of Pharmaceutical Sciences, vol.7, no.1, pp.1-8, 2010 (Scopus) identifier

  • Publication Type: Article / Article
  • Volume: 7 Issue: 1
  • Publication Date: 2010
  • Journal Name: Turkish Journal of Pharmaceutical Sciences
  • Journal Indexes: Scopus, TR DİZİN (ULAKBİM)
  • Page Numbers: pp.1-8
  • Keywords: Alkaloid, Antimicrobial activity, GC-MS, Leguminosae, Sophora jaubertii
  • Istanbul Medipol University Affiliated: No


In this study, the aerial parts and seeds of Sophora jaubertii Spach (leguminosae) growing in Turkey were investigated for their alkaloid compositions and antimicrobial activities. The alkaloid extracts were analyzed by capillary gas chromatography-mass spectrometry (GC-MS). The main components were identified as matrine (34.64 %), sophocarpine (15.32 %), cytisine (10.32 %), anagyrine (9.10 %), and sophoridine (6.35 %) in the aerial parts, while matrine (32.34 %), sophocarpine (14.67 %), cytisine (13.30 %), sophoranol (10.98 %), and sophoridine (8.57 %) in the seeds of the plant. The alkaloid extracts were also evaluated for their antibacterial and antifungal activities. The alkaloid extract of the aerial parts of S. jaubertii presented significant activity against Bacillus subtilis with a minimum inhibitory concentration (MIC) of 31.25 μg/ml. The remaining MIC values were found in the range of 62.5-500 μg/ml.