Maternal serum sestrin 2 levels in preeclampsia and their relationship with the severity of the disease

Tayyar A. T., Tayyar A., Kozali S., Karakus R., Eser A., Abide Yayla C., ...More

Hypertension in Pregnancy, vol.38, no.1, pp.13-19, 2019 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 38 Issue: 1
  • Publication Date: 2019
  • Doi Number: 10.1080/10641955.2018.1540702
  • Journal Name: Hypertension in Pregnancy
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.13-19
  • Keywords: preeclampsia, oxidative stress, sestrin 2
  • Istanbul Medipol University Affiliated: Yes


Objective: To investigate sestrin 2 (SESN2) levels in preeclampsia (PE) cases and uncomplicated pregnancies. Methods: Cross-sectional study including 26 pregnant women with PE, 24 with severe-PE, and 30 randomly selected healthy pregnant women. Results: The mean arterial pressure, severe proteinuria, number of HELLP syndrome cases, and serum SESN2 levels in the severe PE group were significantly higher than those in the other groups (p < 0.001, p < 0.001, p = 0.006, and p = 0.004, respectively). Negative correlation was found between the birth interval (r = −.262, p = 0.019) and the SESN2 level. Conclusion: SESN2 seems to play a role in the pathophysiology of PE, especially in severe PE cases.