Maternal serum sestrin 2 levels in preeclampsia and their relationship with the severity of the disease

Tayyar A. T., Tayyar A., Kozali S., Karakus R., Eser A., Abide Yayla C., ...Daha Fazla

Hypertension in Pregnancy, cilt.38, sa.1, ss.13-19, 2019 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 38 Sayı: 1
  • Basım Tarihi: 2019
  • Doi Numarası: 10.1080/10641955.2018.1540702
  • Dergi Adı: Hypertension in Pregnancy
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.13-19
  • Anahtar Kelimeler: preeclampsia, oxidative stress, sestrin 2
  • İstanbul Medipol Üniversitesi Adresli: Evet

Özet

Objective: To investigate sestrin 2 (SESN2) levels in preeclampsia (PE) cases and uncomplicated pregnancies. Methods: Cross-sectional study including 26 pregnant women with PE, 24 with severe-PE, and 30 randomly selected healthy pregnant women. Results: The mean arterial pressure, severe proteinuria, number of HELLP syndrome cases, and serum SESN2 levels in the severe PE group were significantly higher than those in the other groups (p < 0.001, p < 0.001, p = 0.006, and p = 0.004, respectively). Negative correlation was found between the birth interval (r = −.262, p = 0.019) and the SESN2 level. Conclusion: SESN2 seems to play a role in the pathophysiology of PE, especially in severe PE cases.