Parathyroid allotransplant for persistent hypocalcaemia: A new technique involving short-term culture

Aysan E., Kilic U., GÖK Ö., Altug B., Ercan C., Toka C. K., ...More

Experimental and Clinical Transplantation, vol.14, no.2, pp.238-241, 2016 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 14 Issue: 2
  • Publication Date: 2016
  • Doi Number: 10.6002/ect.2014.0110
  • Journal Name: Experimental and Clinical Transplantation
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.238-241
  • Istanbul Medipol University Affiliated: Yes


Objectives: To develop a new parathyroid allotransplant method for the treatment of permanent hypo - parathyroidism. Materials and Methods: Parathyroid cells 50 × 106 derived from a parathyroid hyperplasia patient were transferred to a 61-year-old patient who had thyroidectomy 17 years earlier, allowing to papillary thyroid cancer; he was admitted to our outpatient clinic with symptomatic chronic hypocalcemia. Cell isolation, cryopreservation, and culturing were conducted according to a new protocol. Results: During a follow-up of 5 months, the patient had no complications that could indicate rejection, and clinical symptoms completely resolved without requiring any drug supplementation. Conclusions: Here, we report a new method, enabling fast and cost-effective parathyroid allotransplant with maintained tissue viability sufficient to treat persistent hypocalcemia.