The Effect of Vitamin E Supplements Added to Clomiphene Citrate Treatment on Fertility in Polycystic Ovary Syndrome


Celal Bayar Üniversitesi Sağlık Bilimleri Enstitüsü Dergisi, vol.8, no.3, pp.443-448, 2021 (Peer-Reviewed Journal) identifier


Objective: This study was designed to investigate the role of vitamin E supplementation during cycles in ovulation induction with clomiphene citrate (CC) in women with infertile Polycystic Ovary Syndrome (PCOS) on ovulation defect, endometrium thickness, clinical and ongoing pregnancy increase. Materials and Methods: In this retrospective case control study, PCOS patients admitting to Yenibosna Private Nisa Hospital Obstetrics Clinic between January 1 st 2015 and October 1 st 2020 for infertility treatment were evaluated. A total of 306 patients were evaluated, including 139 Patients with PCOS receiving CC and vitamin E treatment (Vitamin E group), and 167 patients with PCOS who received CC treatment only (Clomiphene group). The primary result was that the cumulative ovulation rate (i.e. the rate of the cycles in which ovulation occurs during the entire follow-up period), the secondary result was the number of dominant follicles, the endometrial thickness on the day of HCG admission, and the clinical and ongoing pregnancy rates. Results: No statistical differences were detected between the two groups in terms of dominant follicle counts, ovulation rates, and clinical and ongoing pregnancy rates (p>0.05). When the vitamin E group and control group were compared it was determined that there was a statistically significant difference between the groups in terms of endometrial thickness (p<0.000). Conclusion: It was found that vitamin E supplementation given during the cycles was not effective in increasing the number of dominant follicles, ovulation rates, and clinical and ongoing pregnancy rates in infertile women with PCOS, but increased endometrial thickness.