In Vitro Anti-Helicobacter pylori and Antimycobacterial Activity Evaluation of Selected Plants From Turkey

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JOURNAL OF ANATOLIAN ENVIRONMENTAL AND ANIMAL SCIENCES, vol.5, no.2, pp.231-235, 2020 (Peer-Reviewed Journal) identifier


In this study, the extracts of Ulmus minor Mill. subsp. minor (Ulmaceae), Lathyruspratensis L. (Leguminosae), Glaucium leiocarpum Bois. (Papaveraceae), and Echium vulgareL. (Boraginacea) were investigated for their in vitro anti-Helicobacter pylori and antimycobacterial activity.The air-dried plant material was powdered and extracted with 70% ethanol by maceration. Theextract was filtered and evaporated to dryness under the vacuum and then dissolved in a waterethanol (90:10) mixture and extracted with dichloromethane and ethyl acetate, respectively.Antibacterial activity was investigated by microdilution method against Helicobacter pyloriATCC 43504, Mycolicibacterium smegmatis ATCC 14468 and Mycobacterium avium ATCC25291.The ethyl acetate extract of U. minor showed activity with MIC of 250 µg / mL against H. pylori.The other extracts showed no or weak inhibitory activity at >2000 µg/mL concentrations againstthe tested microorganisms. In conclusion, ethyl acetate extract of U. minor may be used for thetreatment of H. pylori infections.