Glymphatic clearance as revealed by diffusion tensor imaging along the perivascular space (DTI-ALPS) is associated with Alzheimer's disease neuropathology and periodic rsEEG alpha rhythms in mild cognitive impairment participants

Lopez, Susanna; Del Percio, Claudio; Lizio, Roberta; Noce, Giuseppe; Carpi, Matteo; Arnaldi, Dario; Famà, Francesco; Pardini, Matteo; Massa, Federico; Marinozzi, Franco; Bini, Fabiano; Treves, Giorgia; Soricelli, Andrea; Salvatore, Marco; Giubilei, Franco; Ziccardi, Laura; GÜNTEKİN, Bahar; YENER, GÖRSEV; Ferri, Raffaele; Lanuzza, Bartolo; Stocchi, Fabrizio; Vacca, Laura; Coletti, Chiara; Infarinato, Francesco; Romano, Paola; Marizzoni, Moira; Frisoni, Giovanni; Barone, Paolo; Cappiello, Arianna; Cuoco, Sofia; Bonanni, Laura; D'Anselmo, Anita; Antonini, Angelo; Fiorenzato, Eleonora; Cauzzo, Simone; Biundo, Roberta; D'Antonio, Fabrizia; De Pandis, Maria; Marziali, Simone; Bruno, Giuseppe; Carducci, Filippo; Babiloni, Claudio

doi:10.1002/dad2.70384

Glymphatic clearance as revealed by diffusion tensor imaging along the perivascular space (DTI-ALPS) is associated with Alzheimer's disease neuropathology and periodic rsEEG alpha rhythms in mild cognitive impairment participants

Lopez S., Del Percio C., Lizio R., Noce G., Carpi M., Arnaldi D., ...Daha Fazla

Alzheimer's and Dementia: Diagnosis, Assessment and Disease Monitoring, cilt.18, sa.2, 2026 (ESCI, Scopus)

Yayın Türü: Makale / Tam Makale
Cilt numarası: 18 Sayı: 2
Basım Tarihi: 2026
Doi Numarası: 10.1002/dad2.70384
Dergi Adı: Alzheimer's and Dementia: Diagnosis, Assessment and Disease Monitoring
Derginin Tarandığı İndeksler: Emerging Sources Citation Index (ESCI), Scopus, EMBASE, Directory of Open Access Journals, Health Research Premium Collection (ProQuest)
Anahtar Kelimeler: Alzheimer's disease, diffusion tensor imaging along the perivascular space, mild cognitive impairment, periodic and aperiodic components of resting state encephalogram power spectral density, resting-state electroencephalographic rhythms, spectral parametrization
İstanbul Medipol Üniversitesi Adresli: Evet

Özet

INTRODUCTION: We evaluated whether the brain glymphatic drainage function estimated by the diffusion tensor imaging along the perivascular space (DTI-ALPS) index relates to white matter (WM) integrity, Alzheimer's disease (AD) neuropathology, resting-state electroencephalogram (rsEEG) alpha rhythms underpinning quiet vigilance, and cognitive decline in mild cognitive impairment (MCI). METHODS: Clinical, neuroimaging, and rsEEG data were analyzed in matched mild cognitive impairment due to AD (ADMCI) and MCI not due to AD (noADMCI) participants. DTI-ALPS index and aperiodic and periodic components of the rsEEG power spectra were calculated following standard pipelines. RESULTS: Lower DTI-ALPS index was associated with higher AD neuropathology and WM lesions, lower periodic rsEEG alpha rhythms, and worse cognition in patients with ADMCI and noADMCI as a whole population, with the ADMCI (over noADMCI) group showing lower DTI-ALPS index, greater AD neuropathology, and lower periodic rsEEG alpha rhythms. CONCLUSIONS: The DTI-ALPS index may capture glymphatic system impairment linked to AD neuropathology, vigilance dysfunction, and cognitive decline in MCI.