The +4259A>C polymorphism of TIM-3 but not -1637C>T polymorphism of TIM-1 is associated with Multiple sclerosis in Isfahan population

Pouladian M., Ganjalikhani-Hakemi M., Alsahebfosul F., Homayouni V., Khosravi S., Etemadifar M., ...More

Multiple Sclerosis and Related Disorders, vol.18, pp.152-156, 2017 (SCI-Expanded) identifier identifier

  • Publication Type: Article / Article
  • Volume: 18
  • Publication Date: 2017
  • Doi Number: 10.1016/j.msard.2017.09.031
  • Journal Name: Multiple Sclerosis and Related Disorders
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.152-156
  • Keywords: Multiple sclerosis, Polymorphism, TIM-1, TIM-3
  • Istanbul Medipol University Affiliated: No


Background Multiple sclerosis (MS) is an inflammatory disease of the central nervous system (CNS) which initiated and mediated by autoreactive T helper1 cells directed against myelin antigens. One of T cell surface receptors is T cell immunoglobulin and mucin domain (TIM) family which its importance in immunology is recently discovered. These molecules have important immunological function by regulation of T effector cells. Methods In the present study, we analyzed the frequency of +4259 A>C polymorphism in TIM-3 and −1637C>T polymorphism in TIM-1 gene in MS patients and healthy controls using restriction fragment length polymorphism-polymerase chain reaction (RFLP-PCR) method. Results We found that the polymorphism +4259 A>C in exon 3 of the TIM-3 gene is associated with susceptibility to the MS (P = 0.029, OR (95%CI) = 1.841) but the other polymorphism, −1637T>C, in the promoter region of TIM-1 is not (p= 0.064). Conclusion Our findings suggest that +4259 A>C polymorphism in TIM-3 gene may be one of the important genetic factors associated with the MS susceptibility among Iranian populations.