Effects of maternal intake of n-3 fatty acids on lipid profile and leptin concentration in cord blood Anne tarafından alınan n-3 yağ asitlerinin kordon kanı lipid profiline ve leptin konsantrasyonuna etkisi

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Marmara Medical Journal, vol.30, no.3, pp.169-176, 2017 (Scopus) identifier identifier

  • Publication Type: Article / Article
  • Volume: 30 Issue: 3
  • Publication Date: 2017
  • Doi Number: 10.5472/marumj.357250
  • Journal Name: Marmara Medical Journal
  • Journal Indexes: Scopus, TR DİZİN (ULAKBİM)
  • Page Numbers: pp.169-176
  • Keywords: Leptin, Fatty acids, Cord blood, Newborn, Pregnancy
  • Istanbul Medipol University Affiliated: Yes


Objectives: Maternal intake of n-3 long chain polyunsaturated fatty acids (LC-PUFAs) has positive effects on fetal development and pregnancy outcomes. Leptin plays an important role in placental transportion of LC-PUFAs. In this study, we aimed to evaluate the effects of maternal n-3 LC-PUFAs intake on anthropometric parameters of mother and newborn, the levels of fatty acids (FAs) and leptin in cord blood. Material and Methods: Thirty-one pregnant women were included. Eighteen were assigned to the control group and 13 received a supplement containing n-3 LC-PUFAs during last trimester of gestation (supplemented group). Physical examinations of the participants were performed and additional data were collected with a questionnaire. FAs and leptin concentrations in cord blood samples were analyzed using gas chromatography mass spectrometry (GC-MS) and enzyme-linked immunosorbent assay (ELISA) kit respectively. Results: A total amount of n-3 PUFAs significantly increased after treatment. n-6/n-3 PUFAs ratios and the leptin levels were lower in the supplemented group (P=0.052, P=0.140 respectively). There were positive correlations between leptin levels and the z scores for birth weight, height and head circumference of the newborns in the control group. The supplementation affected leptin concentration to be positively correlated with n-6/n-3 PUFA ratios. Conclusion: Daily supplementation with n-3 LC-PUFAs might be effective to improve mother and newborn health.